(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Base Information

Chemical Name:(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester
CAS No.:175793-31-4
Molecular Formula:C₅₁H₇₃N₃O₆Si₂
Molecular Weight:880.328
Hs Code.:

(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Synonyms:(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

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Chemical Property of (S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

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Technology Process of (S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

There total 14 articles about (S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 175793-38-1
(4S)-3-benzyl-4-<(1R)-1-<(tert-butyldimethylsilyl)oxy>benzyl>oxazolidine-2,5-dione

: 175793-28-9
(S)-2-[(2S,3R)-2-Amino-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

: 175793-31-4
(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: With sodium azide; In N,N-dimethyl-formamide; for 15h; Ambient temperature;
DOI:10.1039/cc9960000161

Reference yield:

: 175793-33-6
(3R,4R)-1-Benzyl-4-[(R)-1-(tert-butyl-diphenyl-silanyloxy)-2-methyl-propyl]-3-hydroxy-azetidin-2-one

: 175793-31-4
(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / NaOCl, 2,2,6,6-tetramethylpiperidin-1-oxyl, KBr, NaHCO₃, KH₂PO₄-K₂HPO₄ (pH 6.9) / CH₂Cl₂; H₂O

2: 90 percent / NaN₃ / dimethylformamide / 15 h / Ambient temperature

3: 82 percent / H₂ / Pd/C / ethanol / 15 h / 760 Torr / Ambient temperature

4: 65 percent / NaN₃ / dimethylformamide / 15 h / Ambient temperature

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; sodium azide; hydrogen; sodium hydrogencarbonate; potassium bromide; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo952178n

Reference yield:

: 130115-20-7
(3R,4R,4'R)-4-<<<(1,1-Dimethylethyl)dimethylsilyl>oxy>phenylmethyl>-3-phenylmethoxy-1-(phenylmethyl)azetidin-2-one

: 175793-31-4
(S)-2-[(2S,3R)-2-[(2S,3R)-2-Benzylamino-3-(tert-butyl-dimethyl-silanyloxy)-3-phenyl-propionylamino]-3-(tert-butyl-diphenyl-silanyloxy)-4-methyl-pentanoylamino]-4-methyl-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / H₂ / Pd/C / ethanol / 15 h / 760 Torr / Ambient temperature

2: 96 percent / NaOCl, 2,2,6,6-tetramethylpiperidin-1-oxyl, KBr, NaHCO₃, KH₂PO₄-K₂HPO₄ (pH 6.9) / CH₂Cl₂; H₂O

3: 65 percent / NaN₃ / dimethylformamide / 15 h / Ambient temperature

With 2,2,6,6-tetramethyl-piperidine-N-oxyl; sodium hypochlorite; dipotassium hydrogenphosphate; potassium dihydrogenphosphate; sodium azide; hydrogen; sodium hydrogencarbonate; potassium bromide; palladium on activated charcoal; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jo952178n