Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

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Chemical Name:Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester
CAS No.:182928-76-3
Molecular Formula:C₂₀H₁₈O₈
Molecular Weight:386.358
Hs Code.:

Synonyms:Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

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Chemical Property of Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

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Technology Process of Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

There total 8 articles about Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 182928-64-9
Acetic acid (S)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2-hydroxy-6-methoxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

: 182928-76-3
Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

Guidance literature:: With trimethylsilyl iodide; In acetonitrile; at 40 ℃; for 16h;
DOI:10.1246/cl.1996.833

Reference yield:

: 63635-39-2
2,3,4,6-tetrahydroxyacetophenone

: 182928-76-3
Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: 56 percent / NaH

2: 100 percent / ethyl acetate

3: DCC, DMAP

4: 73 percent / 2 N NaOH / methanol / 40 °C

5: piperidine / 1 h / 80 °C

6: 95 percent / pyridine

7: 75 percent / Me₃SiI / acetonitrile / 16 h / 40 °C

With piperidine; pyridine; dmap; sodium hydroxide; trimethylsilyl iodide; sodium hydride; dicyclohexyl-carbodiimide; In methanol; ethyl acetate; acetonitrile;
DOI:10.1246/cl.1996.833

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 182928-76-3
Acetic acid (R)-3-[(E)-3-(4-acetoxy-phenyl)-acryloyl]-2,6-dihydroxy-1-methyl-4-oxo-cyclohexa-2,5-dienyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: piperidine / 1 h / 80 °C

2: 95 percent / pyridine

3: 75 percent / Me₃SiI / acetonitrile / 16 h / 40 °C

With piperidine; pyridine; trimethylsilyl iodide; In acetonitrile;
DOI:10.1246/cl.1996.833