(E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

Base Information

Chemical Name:(E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride
CAS No.:134405-70-2
Molecular Formula:C₂₄H₂₅ClN₂O₂*ClH
Molecular Weight:445.389
Hs Code.:

Synonyms:(E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

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Technology Process of (E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

There total 11 articles about (E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 134405-87-1
ethyl (E)-3-[2-n-butyl-1-{(2-chlorophenyl)methyl}-1H-imidazol-5-yl]-4-phenyl-2-butenoate

: 134405-70-2
(E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

Guidance literature:: With hydrogenchloride; In ethanol; at 100 ℃; for 6h;
DOI:10.1021/jm00099a013

Reference yield:

: 718-08-1
ethyl 3-oxo-4-phenylbutyrate

: 134405-70-2
(E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 30 min, 2.) DMF, RT, 2 h

2: 1.) n-BuLi, 2.) ZnCl₂, 3.) (Ph₃P)4Pd

3: 5N aq. HCl / methanol / 3.5 h / 60 - 65 °C

4: triethylamine / methanol / 22 h / 25 °C

5: CH₂Cl₂ / 18 h / Ambient temperature

6: 65 percent / 5N HCl / ethanol / 6 h / 100 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; triethylamine; zinc(II) chloride; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00099a013

Reference yield:

: 50790-93-7
2-butyl-1H-imidazole

: 134405-70-2
(E)-3-<2-butyl-1-<(2-chlorophenyl)methyl>imidazol-5-yl>-4-phenyl-2-butenoic acid hydrochloride

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) NaH / 1.) DMF, RT, 1 h, 2.) DMF, RT, 19 h

2: 1.) n-BuLi, 2.) ZnCl₂, 3.) (Ph₃P)4Pd

3: 5N aq. HCl / methanol / 3.5 h / 60 - 65 °C

4: triethylamine / methanol / 22 h / 25 °C

5: CH₂Cl₂ / 18 h / Ambient temperature

6: 65 percent / 5N HCl / ethanol / 6 h / 100 °C

With hydrogenchloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; sodium hydride; triethylamine; zinc(II) chloride; In methanol; ethanol; dichloromethane;
DOI:10.1021/jm00099a013