Technology Process of 2-((5-(benzyloxy)indan-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole
There total 8 articles about 2-((5-(benzyloxy)indan-2-yl)(tert-butyldimethylsilyloxy)methyl)oxazole which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
1.2: 0.67 h / -78 °C
1.3: 2 h / -78 °C
2.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
With
1H-imidazole; borane-THF;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: sodium hydride / tetrahydrofuran / 0 °C / Inert atmosphere; Reflux
2.1: palladium 10% on activated carbon; perchloric acid; hydrogen; acetic acid / 16 h
3.1: water; hydrogen bromide; acetic acid / 2 h / Inert atmosphere; Reflux
4.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
5.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
6.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
7.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
8.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
8.2: 0.67 h / -78 °C
8.3: 2 h / -78 °C
9.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
With
1H-imidazole; lithium aluminium tetrahydride; perchloric acid; borane-THF; sulfuric acid; palladium 10% on activated carbon; water; hydrogen bromide; hydrogen; sodium hydride; Dess-Martin periodane; acetic acid; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
5.1: Mitsunobu alkylation;
DOI:10.1021/jm101597x
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid / 1 h / Inert atmosphere; Reflux
2.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C
4.1: Dess-Martin periodane / dichloromethane / 2 h / 20 °C
5.1: borane-THF / tetrahydrofuran / 1 h / 20 °C
5.2: 0.67 h / -78 °C
5.3: 2 h / -78 °C
6.1: 1H-imidazole / N,N-dimethyl-formamide / 16 h / 20 °C
With
1H-imidazole; lithium aluminium tetrahydride; borane-THF; sulfuric acid; Dess-Martin periodane; triphenylphosphine; diethylazodicarboxylate;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
2.1: Mitsunobu alkylation;
DOI:10.1021/jm101597x
