2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

Base Information

Chemical Name:2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone
CAS No.:142811-47-0
Molecular Formula:C₁₉H₂₆N₆O₆
Molecular Weight:434.452
Hs Code.:

2-amino-6-<<2'(R)-<N-(tert-butoxycarbonyl)-N-benzylamino>-3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

Synonyms:2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

Chemical Property:

Purity/Quality:

Safty Information:

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Hazard Codes:

MSDS Files:: SDS file from LookChem

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Technology Process of 2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

There total 6 articles about 2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 142811-48-1
[(R)-2-(2-Amino-5-nitro-6-oxo-1,6-dihydro-pyrimidin-4-ylamino)-1-formyl-ethyl]-benzyl-carbamic acid tert-butyl ester

: 142811-47-0
2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

Guidance literature:: With sodium tetrahydroborate; In water; N,N-dimethyl-formamide;
DOI:10.1021/jo00042a030

Reference yield: 93.0%

: 24424-99-5
di-tert-butyl dicarbonate

: 142811-46-9
2-amino-6<<2'(R)-(benzylamino)-3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

: 142811-47-0
2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

Guidance literature:: With sodium hydroxide; In 1,4-dioxane; for 46h; Ambient temperature;
DOI:10.1021/jo00042a030

Reference yield:

: 142811-44-7
N-benzyl-L-serinamide hydrochloride

: 142811-47-0
2-amino-6-<<2'(R)--3'-hydroxypropyl>amino>-5-nitro-4(3H)-pyrimidinone

Guidance literature:: Multi-step reaction with 3 steps

1: 56 percent / borane-Me₂S / tetrahydrofuran / 2 h / Heating

2: 70 percent / N,N-diisopropylethylamine -> pH 8 / ethanol / 2 h / Heating

3: 93 percent / 1 M aq. NaOH -> pH 9.5 / dioxane / 46 h / Ambient temperature

With sodium hydroxide; dimethylsulfide borane complex; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; ethanol;
DOI:10.1021/jo00042a030