ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

Base Information

Chemical Name:ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate
CAS No.:153080-93-4
Molecular Formula:C₂₀H₂₄F₃NO₅
Molecular Weight:415.409
Hs Code.:

Synonyms:ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

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Chemical Property of ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

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Technology Process of ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

There total 5 articles about ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

: Ethyl (2S,E)-1-(tert-butoxycarbonyl)-4-<methylidene>pyroglutamate

: 153080-93-4
ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; for 4h; Ambient temperature;
DOI:10.1021/jo00114a054

Reference yield: 20.0%

: 153080-88-7
ethyl (2S,4R)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

: 153080-93-4
ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

Guidance literature:: With potassium cyanide; In N,N-dimethyl-formamide; for 18h; Ambient temperature;
DOI:10.1016/S0040-4020(01)96272-6

Reference yield:

: (S)-5-Oxo-4-[1-(4-trifluoromethyl-phenyl)-meth-(E)-ylidene]-pyrrolidine-1,2-dicarboxylic acid 1-tert-butyl ester 2-ethyl ester

: 153080-93-4
ethyl (2S,4S)-1-(tert-butoxycarbonyl)-4-(p-trifluoromethyl)benzylpyroglutamate

Guidance literature:: With hydrogen; platinum(IV) oxide; In ethyl acetate; for 4h; under 760 Torr; Yield given; Ambient temperature;
DOI:10.1016/S0960-894X(98)00091-2