N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

Base Information

Chemical Name:N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester
CAS No.:115141-33-8
Molecular Formula:C₅₂H₆₆N₆O₁₂
Molecular Weight:967.129
Hs Code.:

Synonyms:N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

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Chemical Property of N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

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Technology Process of N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

There total 1 articles about N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 3978-80-1
Boc-Tyr-OH

: 115160-78-6
H-D-Ser-(CH₂Ph)-Gly-Phe-Leu-Thr-OCH₂Ph*F₃CCOOH

: 115141-33-8
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

Guidance literature:: With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In tetrahydrofuran; chloroform; triethylamine; 0 deg C, 1 h; overnight;
DOI:10.1021/jm00118a005

Reference yield: 80.0%

: 115141-33-8
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

: 115141-34-9
Boc-Tyr-D-Ser(O-Bzl)-Gly-Phe-Leu-Thr

Guidance literature:: With sodium hydroxide; In methanol; for 6h; Ambient temperature;
DOI:10.1021/jm00118a005

Reference yield:

: 115141-33-8
N-(tert-butyloxycarbonyl)-L-tyrosyl-O-benzyl-D-serylglycyl-L-phenylalanyl-L-leucyl-L-threonine benzyl ester

: 82015-09-6
Tyr-D-Ser(O-Bzl)-Gly-Phe-Leu-Thr

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / 1 N NaOH / methanol / 6 h / Ambient temperature

2: 91 percent / trifluoroacetic acid / 0 deg C, 30 min, RT, 30 min

With sodium hydroxide; In methanol; trifluoroacetic acid;
DOI:10.1021/jm00118a005