Technology Process of Cyclohexanepropanoic acid, alpha-amino-2-(2-phosphonoethyl)-
There total 42 articles about Cyclohexanepropanoic acid, alpha-amino-2-(2-phosphonoethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 9 steps
1: 78 percent / LiEt3BH / tetrahydrofuran / Ambient temperature
2: DIBAL / toluene / 1 h / -45 - -35 °C
3: NaH / tetrahydrofuran; toluene / 1.) r.t., 1 h, 2.) 0 deg C, 30 min; 60 deg C, 4 h
4: 88 percent / pyridine-SO3, Et3N / dimethylsulfoxide / 4 h / Ambient temperature
5: 70 percent / LiOH*H2O / aq. ethanol / 0 deg C, 1 h; r.t., 2 h
6: 95 percent / H2 / Raney nickel / methanol / 48 h / 65 °C / 25857.4 Torr
7: D-hydantoinase
8: 70 percent / NaNO2, aq. HCl
9: 100 percent / 10N aq. HCl / 48 h / 95 °C
With
hydrogenchloride; lithium hydroxide; D-hydantoinase; hydrogen; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; lithium triethylborohydride; triethylamine; sodium nitrite;
nickel;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00077a058
- Guidance literature:
-
Multi-step reaction with 8 steps
1: DIBAL / toluene / 1 h / -45 - -35 °C
2: NaH / tetrahydrofuran; toluene / 1.) r.t., 1 h, 2.) 0 deg C, 30 min; 60 deg C, 4 h
3: 88 percent / pyridine-SO3, Et3N / dimethylsulfoxide / 4 h / Ambient temperature
4: 70 percent / LiOH*H2O / aq. ethanol / 0 deg C, 1 h; r.t., 2 h
5: 95 percent / H2 / Raney nickel / methanol / 48 h / 65 °C / 25857.4 Torr
6: D-hydantoinase
7: 70 percent / NaNO2, aq. HCl
8: 100 percent / 10N aq. HCl / 48 h / 95 °C
With
hydrogenchloride; lithium hydroxide; D-hydantoinase; hydrogen; sulfur trioxide pyridine complex; sodium hydride; diisobutylaluminium hydride; triethylamine; sodium nitrite;
nickel;
In
tetrahydrofuran; methanol; ethanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jo00077a058