p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

Base Information

Chemical Name:p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside
CAS No.:1334709-86-2
Molecular Formula:C₅₁H₆₄ClN₃O₁₂SSi
Molecular Weight:1006.69
Hs Code.:

p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

Synonyms:p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

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Chemical Property of p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

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Technology Process of p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

There total 1 articles about p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 1242437-13-3
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-1-thio-β-D-glucopyranoside

: 1334709-85-1
p-tolyl 3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

: 1334709-86-2
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

Guidance literature:: p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-1-thio-β-D-glucopyranoside; With silver trifluoromethanesulfonate; In diethyl ether; dichloromethane; at -78 ℃; for 0.0833333h; Inert atmosphere; Molecular sieve;

With p-methylbenzenesulfenyl chloride; In diethyl ether; dichloromethane; at -78 ℃; for 0.0833333h; Inert atmosphere;

p-tolyl 3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside; With tri-tert-butyl phosphine; In diethyl ether; dichloromethane; at -78 - -20 ℃; for 2h; Inert atmosphere;
DOI:10.1002/chem.201101108

Reference yield: 63.0%

: 1334709-86-2
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

: 1334709-87-3
C₄₃H₅₆ClN₃O₁₁SSi

Guidance literature:: With water; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane; at 0 - 20 ℃; for 8h; Inert atmosphere;
DOI:10.1002/chem.201101108

Reference yield:

: 1334709-86-2
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-p-methoxybenzyl-1-thio-β-D-glucopyranoside

: 1334709-59-9
p-tolyl 6-O-acetyl-2-azido-3-O-benzyl-4-O-tert-butyldimethylsilyl-2-deoxy-α-D-glucopyranosyl-(1->4)-3-O-benzyl-2-O-chloroacetyl-6-O-levulinoyl-1-thio-β-D-glucopyranoside

Guidance literature:: Multi-step reaction with 2 steps

1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 8 h / 0 - 20 °C / Inert atmosphere

2: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 8 h / 20 °C / Inert atmosphere

With dmap; water; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; 2,3-dicyano-5,6-dichloro-p-benzoquinone; In dichloromethane;
DOI:10.1002/chem.201101108