3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

Base Information

Chemical Name:3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile
CAS No.:1609547-79-6
Molecular Formula:C₂₁H₂₄ClN₅O₃S
Molecular Weight:461.972
Hs Code.:

Synonyms:3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

Suppliers and Price of 3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

There total 8 articles about 3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 1609547-77-4
S-(4-cyano-1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)butan-2-yl) O-ethyl carbonodithioate

: 1609547-79-6
3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

Guidance literature:: With 2,6-dimethylpyridine; dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;
DOI:10.1021/ol501104h

Reference yield: 26.0%

: 1609547-77-4
S-(4-cyano-1-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)butan-2-yl) O-ethyl carbonodithioate

: 1609547-78-5
C₂₁H₂₅Cl₂N₅O₂S

: 1609547-79-6
3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

: 1609547-80-9
4-chloro-5-(4-((4,6-dichloropyrimidin-2-yl)amino)-1-tosylpiperidin-4-yl)pentanenitrile

Guidance literature:: With dilauryl peroxide; In ethyl acetate; Inert atmosphere; Reflux;
DOI:10.1021/ol501104h

Reference yield:

: 1609547-75-2
N-(4-allyl-1-tosylpiperidin-4-yl)-4,6-dichloropyrimidin-2-amine

: 1609547-79-6
3-(6'-chloro-8'-oxo-1-tosyl-1',3',4',8'-tetrahydrospiro[piperidine-4,2'-pyrimido[1,2-a]pyrimidin]-4'-yl)propanenitrile

Guidance literature:: Multi-step reaction with 2 steps

1: dilauryl peroxide / ethyl acetate / Inert atmosphere; Reflux

2: dilauryl peroxide; 2,6-dimethylpyridine / ethyl acetate / Inert atmosphere; Reflux

With 2,6-dimethylpyridine; dilauryl peroxide; In ethyl acetate;
DOI:10.1021/ol501104h