1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Base Information

Chemical Name:1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol
CAS No.:1350714-44-1
Molecular Formula:C₂₈H₃₉N₃O₂
Molecular Weight:449.637
Hs Code.:

Synonyms:1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

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Chemical Property of 1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

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Technology Process of 1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

There total 4 articles about 1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 1350714-34-9
17β-acetoxy-1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstan-3β-ol

: 1350714-44-1
1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Guidance literature:: With methanol; potassium hydroxide; at 20 ℃; for 24h;
DOI:10.1039/c1ob06086d

Reference yield:

: 1350714-19-0
17β-acetoxy-1α-azido-5α-androstan-3-one

: 1350714-44-1
1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Guidance literature:: Multi-step reaction with 3 steps

1: potassium borohydride; acetic acid / methanol / 3 h / pH 6 - 8

2: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 3 h / 111 °C

3: methanol; potassium hydroxide / 24 h / 20 °C

With methanol; copper(l) iodide; potassium borohydride; acetic acid; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In methanol; toluene;
DOI:10.1039/c1ob06086d

Reference yield:

: 1350714-20-3
17β-acetoxy-1α-azido-5α-androstan-3β-ol

: 1350714-44-1
1α-[4'-(4''-tolyl)-1'H-1',2',3'-triazol-1'-yl]-5α-androstane-3β,17β-diol

Guidance literature:: Multi-step reaction with 2 steps

1: copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine / toluene / 3 h / 111 °C

2: methanol; potassium hydroxide / 24 h / 20 °C

With methanol; copper(l) iodide; N-ethyl-N,N-diisopropylamine; triphenylphosphine; potassium hydroxide; In toluene;
DOI:10.1039/c1ob06086d