(1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Base Information

Chemical Name:(1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol
CAS No.:179077-94-2
Molecular Formula:C₂₁H₂₅ClN₂OS
Molecular Weight:388.961
Hs Code.:

Synonyms:(1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Suppliers and Price of (1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

There total 1 articles about (1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 622-95-7
4-chlorobenzyl bromide

: 176896-76-7
(1S,2S,5S)-2-hydroxy-3-(thiazol-2-ylmethylimino)pinane

: 179077-94-2
(1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

Guidance literature:: With lithium diisopropyl amide; In tetrahydrofuran; hexane; at -80 ℃; for 1h;
DOI:10.1055/s-1996-4259

Reference yield:

: 179077-94-2
(1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

: (R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylamine

Guidance literature:: With sodium hydroxide; hydroxylamine hydrochloride; acetic acid; In methanol; at 0 ℃; for 5h;
DOI:10.1055/s-1996-4259

Reference yield:

: 179077-94-2
(1S,2S,5S)-3-[(E)-(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethylimino]-2,6,6-trimethyl-bicyclo[3.1.1]heptan-2-ol

: [(R)-2-(4-Chloro-phenyl)-1-thiazol-2-yl-ethyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: NaOH, hydroxylamine hydrochloride, HOAc / methanol / 5 h / 0 °C

2: dioxane / Ambient temperature

With sodium hydroxide; hydroxylamine hydrochloride; acetic acid; In 1,4-dioxane; methanol;
DOI:10.1055/s-1996-4259