3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Chemical Name:3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one
CAS No.:1441049-56-4
Molecular Formula:C₂₃H₂₀F₆N₂O₄
Molecular Weight:502.413
Hs Code.:

Synonyms:3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Chemical Property of 3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

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Technology Process of 3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

There total 9 articles about 3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 17.0%

: 1441058-22-5
2-nitro-N-(1,1,1-trifluoro-4-oxo-4-p-tolyl-2-(4-(4,4,4-trifluorobutoxy)phenyl)butan-2-yl)-acetamide

: 1441049-56-4
3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: With piperidine; In methanol; at 75 ℃; for 1.5h;

Reference yield:

: 280776-44-5
4-(4,4,4-trifluorobutoxy)benzaldehyde

: 1441049-56-4
3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 6 steps

1: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

2: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

3: dimethyl sulfoxide / 160 °C / Microwave irradiation

4: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

5: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 70 °C

6: piperidine / methanol / 1.5 h / 75 °C

With piperidine; ammonium hydroxide; Dess-Martin periodane; dicyclohexyl-carbodiimide; cesium fluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;

Reference yield:

: 123-08-0,65581-83-1
4-hydroxy-benzaldehyde

: 1441049-56-4
3-nitro-4-p-tolyl-6-(4-(4,4,4-trifluorobutoxy)phenyl)-6-(trifluoromethyl)-5,6-dihydropyridin-2(1H)-one

Guidance literature:: Multi-step reaction with 7 steps

1: di-isopropyl azodicarboxylate; triphenylphosphine / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2: cesium fluoride / 1,2-dimethoxyethane / 16 h / 20 °C

3: Dess-Martin periodane / dichloromethane / 3.5 h / 0 - 20 °C

4: dimethyl sulfoxide / 160 °C / Microwave irradiation

5: ammonium hydroxide / dimethyl sulfoxide; water / 48 h / Sealed tube

6: dicyclohexyl-carbodiimide / tetrahydrofuran / 0 - 70 °C

7: piperidine / methanol / 1.5 h / 75 °C

With piperidine; ammonium hydroxide; di-isopropyl azodicarboxylate; Dess-Martin periodane; dicyclohexyl-carbodiimide; triphenylphosphine; cesium fluoride; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; dimethyl sulfoxide;