N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

Base Information

Chemical Name:N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide
CAS No.:128577-35-5
Molecular Formula:C₂₉H₃₁N₃O₅S
Molecular Weight:533.648
Hs Code.:

Synonyms:N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

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Technology Process of N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

There total 8 articles about N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 50715-28-1
cyclopentyl chloroformate

: 128577-26-4
N-[4-(6-Amino-indol-1-ylmethyl)-3-methoxy-benzyl]-benzenesulfonamide

: 128577-35-5
N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; Ambient temperature;
DOI:10.1021/jm00171a018

Reference yield:

: 4769-96-4
6-nitroindole

: 128577-35-5
N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 90 percent / K₂CO₃ / acetone / Heating

2: 1.) BH₃, 2.) 12 N HCl / 1.) THF, reflux, 1 h, 2.) reflux, 1 h

3: 25 percent / 1.) 2,6-lutidine / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) DMF, RT, 24 h

4: H₂ / 10percent Pd/C / ethyl acetate / 22.5 h

5: 38 percent / 2,6-lutidine / CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; borane; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm00171a018

Reference yield:

: 7151-68-0
3-methoxy-p-toluic acid

: 128577-35-5
N-<4-<<6-(cyclopentyloxycarbonylamino)indol-1-yl>methyl>-3-methoxybenzyl>benzenesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: 60 percent / chlorosulfonyl isocyanate / CH₂Cl₂ / 0.75 h / Heating

2: 65 percent / N-bromosuccinimide (NBS), benzoyl peroxide / CCl₄ / 0.25 h / Heating; Irradiation

3: 90 percent / K₂CO₃ / acetone / Heating

4: 1.) BH₃, 2.) 12 N HCl / 1.) THF, reflux, 1 h, 2.) reflux, 1 h

5: 25 percent / 1.) 2,6-lutidine / tetrahydrofuran / 1.) 0 deg C, 1 h, 2.) DMF, RT, 24 h

6: H₂ / 10percent Pd/C / ethyl acetate / 22.5 h

7: 38 percent / 2,6-lutidine / CH₂Cl₂ / Ambient temperature

With 2,6-dimethylpyridine; hydrogenchloride; N-Bromosuccinimide; Perbenzoic acid; isocyanate de chlorosulfonyle; borane; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; tetrachloromethane; dichloromethane; ethyl acetate; acetone;
DOI:10.1021/jm00171a018