2-cyclobutyl-1,1,2-triphenylpropanol

Base Information

• Chemical Name: 2-cyclobutyl-1,1,2-triphenylpropanol
• CAS No.: 123078-60-4
• Molecular Formula: C₂₅H₂₆O
• Molecular Weight: 342.481
• Mol file: 123078-60-4.mol

Synonyms:2-cyclobutyl-1,1,2-triphenylpropanol

Chemical Property of 2-cyclobutyl-1,1,2-triphenylpropanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-cyclobutyl-1,1,2-triphenylpropanol

There total 9 articles about 2-cyclobutyl-1,1,2-triphenylpropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

2-cyclobutyl-2-phenylpropiophenone (123078-58-0) + phenyllithium (591-51-5) → 2-cyclobutyl-1,1,2-triphenylpropanol (123078-60-4)

Guidance literature:

In diethyl ether; at -78 ℃; for 1h;

DOI:10.1021/jo00282a020

Reference yield:

cyclobutylphenylacetaldehyde (123078-48-8) → 2-cyclobutyl-1,1,2-triphenylpropanol (123078-60-4)

Guidance literature:

Multi-step reaction with 8 steps

1: 71 percent / silver nitrate, sodium hydroxide / H₂O; ethanol / 24 h / Ambient temperature

2: thionyl chloride, pyridine / benzene / 6 h / Ambient temperature

3: 2 h

4: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C

5: 99 percent / diisobutylaluminum hydride (Dibal-H) / CH₂Cl₂; hexane / 1 h / -10 °C

6: 93 percent / chromium trioxide, pyridine / CH₂Cl₂ / 0 °C

7: 2.) chromium trioxide, pyridine

8: 97 percent / diethyl ether / 1 h / -78 °C

With pyridine; chromium(VI) oxide; sodium hydroxide; thionyl chloride; diisobutylaluminium hydride; silver nitrate; lithium diisopropyl amide; In diethyl ether; ethanol; hexane; dichloromethane; water; benzene;

DOI:10.1021/jo00282a020

Reference yield:

α-cyclobutylphenylacetic acid (123078-51-3) → 2-cyclobutyl-1,1,2-triphenylpropanol (123078-60-4)

Guidance literature:

Multi-step reaction with 7 steps

1: thionyl chloride, pyridine / benzene / 6 h / Ambient temperature

2: 2 h

3: 1.) lithium diisopropylamide (LDA) / 1.) THF, -78 deg C, 15 min, 2.) from -30 deg C to 0 deg C

4: 99 percent / diisobutylaluminum hydride (Dibal-H) / CH₂Cl₂; hexane / 1 h / -10 °C

5: 93 percent / chromium trioxide, pyridine / CH₂Cl₂ / 0 °C

6: 2.) chromium trioxide, pyridine

7: 97 percent / diethyl ether / 1 h / -78 °C

With pyridine; chromium(VI) oxide; thionyl chloride; diisobutylaluminium hydride; lithium diisopropyl amide; In diethyl ether; hexane; dichloromethane; benzene;

DOI:10.1021/jo00282a020

upstream raw materials:

2-cyclobutyl-2-phenylpropiophenone

phenyllithium

cyclobutylphenylacetaldehyde

α-cyclobutylphenylacetic acid