4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride

Base Information

• Chemical Name: 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride
• CAS No.: 56892-71-8
• Molecular Formula: C₂₀H₂₃N₇O₄
• Molecular Weight: 425.447

Synonyms:4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride

Chemical Property of 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride

Chemical Property:

Purity/Quality:

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MSDS Files:

SDS file from LookChem

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Technology Process of 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride

There total 2 articles about 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid (19741-14-1) + isobutyl chloroformate (543-27-1) → 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride (56892-71-8)

Guidance literature:

With 4-methyl-morpholine; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 0 ℃; for 30h;

DOI:10.1021/jm00164a038

Reference yield:

→ 4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride (56892-71-8)

Guidance literature:

aus 4-Amino-4-deoxy-N10-methyl-pteroic acid in DMF mit Triaethylamin u. Chlorameisensaeure-isobutylester (20grad);

DOI:10.1021/jm00243a010

Reference yield:

4-[(2,4-diamino-pteridin-6-ylmethyl)-methyl-amino]-benzoic O-isobutyl-carbonic anhydride (56892-71-8) + (S)-2-amino-5-(((benzyloxy)carbonyl)amino)pentanoic acid tert-butyl ester (53054-01-6) → Nα-(4-amino-4-deoxy-N10-methylpteroyl)-Nδ-carbobenzoxy-L-ornithine tert-butyl ester (80407-76-7)

Guidance literature:

With 4-methyl-morpholine; In various solvent(s); at 60 ℃; for 1h; Yield given;

DOI:10.1021/jm00346a026

upstream raw materials:

4-[(2,4-diaminopteridin-6-ylmethyl)methylamino]benzoic acid

isobutyl chloroformate

Downstream raw materials:

α-tert-butyl 4-amino-4-deoxy-N¹⁰-methylpteroyltetraglutamate

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine tert-butyl ester

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^ε-carbobenzoxy-L-lysine tert-butyl ester

N^α-(4-amino-4-deoxy-N¹⁰-methylpteroyl)-N^δ-carbobenzoxy-L-ornithine

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