methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Base Information

Chemical Name:methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate
CAS No.:1379595-99-9
Molecular Formula:C₂₀H₂₁ClN₂O₄
Molecular Weight:388.851
Hs Code.:

Synonyms:methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Suppliers and Price of methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Chemical Property:

Purity/Quality:: 95%-98% ^*data from raw suppliers

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Technology Process of methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

There total 3 articles about methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 118081-77-9
3-(Ethyl(phenyl)amino)-3-oxopropanoic acid

: 1379595-97-7
methyl 2-chloro-6-(methylamino)benzoate

: 1379595-99-9
methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Guidance literature:: 3-(Ethyl(phenyl)amino)-3-oxopropanoic acid; With pyridine; In dichloromethane; at 20 - 25 ℃; for 0.5h; Inert atmosphere;

With pivaloyl chloride; In Dichlorodifluoromethane; at 0 - 5 ℃; for 1h;

methyl 2-chloro-6-(methylamino)benzoate; In dichloromethane; at 0 - 20 ℃; Product distribution / selectivity;

Reference yield:

: 103-69-5
N-ethyl-N-phenylamine

: 1379595-99-9
methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 14 h / 20 °C / Inert atmosphere

2.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

2.2: 0 - 5 °C / pH 2 - 3

3.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere

3.2: 1 h / 0 - 5 °C

3.3: 0 - 20 °C

With pyridine; water; lithium hydroxide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 142613-14-7
methyl 3-(N-ethyl-N-phenylamino)-3-oxopropionate

: 1379595-99-9
methyl 2-chloro-6-[[3-(ethyl(phenyl)amino)-3-oxopropanoyl]methylamino]benzoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: water; lithium hydroxide / tetrahydrofuran / 1.5 h / 20 °C

1.2: 0 - 5 °C / pH 2 - 3

2.1: pyridine / dichloromethane / 0.5 h / 20 - 25 °C / Inert atmosphere

2.2: 1 h / 0 - 5 °C

2.3: 0 - 20 °C

With pyridine; water; lithium hydroxide; In tetrahydrofuran; dichloromethane;