6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

Base Information

• Chemical Name: 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione
• CAS No.: 130681-00-4
• Molecular Formula: C₂₇H₂₆N₄O₃
• Molecular Weight: 454.528
• Mol file: 130681-00-4.mol

Synonyms:6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

Chemical Property of 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

There total 7 articles about 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

aqueous perchloric acid + 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-(2-propenyloxy)phenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione (129095-27-8) → 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione (130681-00-4)

Guidance literature:

With perchloric acid; palladium; In ethanol; chloroform;

Reference yield: 68.0%

6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-(2-propenyloxy)phenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione (129095-27-8) → 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione (130681-00-4)

Guidance literature:

With palladium on activated charcoal; perchloric acid; In ethanol; for 29h; Heating;

DOI:10.1021/jm00109a028

Reference yield:

ethyl 4-(n-prop-2'-enyloxy)benzoate (5443-37-8) → 6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-hydroxyphenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione (130681-00-4)

Guidance literature:

Multi-step reaction with 5 steps

1: C₂H₅ONa / toluene / 24 h / 108 °C

2: H₂N-NH₂*H₂O / aq. ethanol / 2 h / Heating

3: 89 percent / aq. ethanol / 24 h / Heating

4: 93 percent / K₂CO₃ / dimethylformamide / 24 h / Ambient temperature

5: 68 percent / 10percent Pd/C, 70percent aq. perchloric acid / aq. ethanol / 29 h / Heating

With palladium on activated charcoal; perchloric acid; sodium ethanolate; potassium carbonate; hydrazine hydrate; In ethanol; N,N-dimethyl-formamide; toluene;

DOI:10.1021/jm00109a028

upstream raw materials:

6-cyclohexyl-6,7-dihydro-4-(phenylmethyl)-2-(4-(2-propenyloxy)phenyl)-4H-pyrazolo<1,5-a>pyrrolo<3,4-d>pyrimidine-5,8-dione

ethyl 4-(n-prop-2'-enyloxy)benzoate

benzyl bromide

3-(4-(allyloxy)phenyl)-3-oxopropanenitrile