6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

Base Information

Chemical Name:6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran
CAS No.:139201-39-1
Molecular Formula:C₂₉H₃₂O₃S
Molecular Weight:460.637
Hs Code.:

Synonyms:6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

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Chemical Property of 6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

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Technology Process of 6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

There total 7 articles about 6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-44-7
benzyl chloride

: 139201-39-1
6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

Guidance literature:: Multi-step reaction with 3 steps

1: 92 percent / K₂CO₃ / butan-2-one / 25 h / Heating

2: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C, 20 min

3: 1.) Mg / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

With oxalyl dichloride; potassium carbonate; magnesium; dimethyl sulfoxide; In butanone;
DOI:10.1021/jm00085a019

Reference yield:

: 13380-24-0
2,3-dihydro-3,3-dimethyl-2-methoxy-5-benzofuranol

: 139201-39-1
6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

Guidance literature:: Multi-step reaction with 7 steps

1: 77 percent / K₂CO₃ / butan-2-one / 4 h / Heating

2: 75 percent / 1,2-dichloro-benzene / 18 h / Heating

3: 82 percent / tetrahydrofuran / 20 h / Heating

4: 97 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 0.17 h / 5 °C

5: 92 percent / K₂CO₃ / butan-2-one / 25 h / Heating

6: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C, 20 min

7: 1.) Mg / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

With oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; magnesium; dimethyl sulfoxide; In tetrahydrofuran; 1,2-dichloro-benzene; toluene; butanone;
DOI:10.1021/jm00085a019

Reference yield:

: 138854-54-3
6-allyl-2,3-dihydro-3,3-dimethyl-2-methoxy-5-benzofuranol

: 139201-39-1
6-allyl-5-(benzyloxy)-2,3-dihydro-3,3-dimethyl-2-<2-hydroxy-2-<4-(methylthio)phenyl>ethyl>benzofuran

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / tetrahydrofuran / 20 h / Heating

2: 97 percent / diisobutylaluminum hydride / tetrahydrofuran; toluene / 0.17 h / 5 °C

3: 92 percent / K₂CO₃ / butan-2-one / 25 h / Heating

4: 1.) DMSO, oxalyl chloride / 1.) CH₂Cl₂, -78 deg C, 2.) CH₂Cl₂, -78 deg C, 20 min

5: 1.) Mg / 1.) THF, reflux, 2 h, 2.) THF, RT, 1 h

With oxalyl dichloride; diisobutylaluminium hydride; potassium carbonate; magnesium; dimethyl sulfoxide; In tetrahydrofuran; toluene; butanone;
DOI:10.1021/jm00085a019