4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

Base Information

• Chemical Name: 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one
• CAS No.: 1610599-86-4
• Molecular Formula: C₃₅H₃₀BrF₃N₂O₃
• Molecular Weight: 663.534
• Mol file: 1610599-86-4.mol

Synonyms:4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

Chemical Property of 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one

There total 4 articles about 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

(R)-1-phenyl-ethyl-amine (3886-69-9) + C27H21BrF3NO4 (1610600-03-7) → 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one (1610599-86-4)

Guidance literature:

In acetic acid; at 120 ℃; for 2h; Microwave irradiation;

DOI:10.1016/j.bmcl.2014.04.063

Reference yield:

2-fluoro-4-(trifluoromethyl)benzonitrile (146070-34-0) → 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one (1610599-86-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hydride / 12 h / 0 - 20 °C

2.1: lithium aluminium tetrahydride / 12 h / 0 - 20 °C

3.1: 1,4-dioxane / 0.17 h / 20 °C

3.2: 12 h

4.1: acetic acid / 2 h / 120 °C / Microwave irradiation

With lithium aluminium tetrahydride; sodium hydride; In 1,4-dioxane; acetic acid;

DOI:10.1016/j.bmcl.2014.04.063

Reference yield:

2-ethoxy-4-trifluoromethyl-benzonitrile (548785-17-7) → 4-benzoyl-5-(4-bromophenyl)-1-(2-ethoxy-4-(trifluoromethyl)phenyl)-3-((R)-1-phenylethylamino)-1H-pyrrol-2(5H)-one (1610599-86-4)

Guidance literature:

Multi-step reaction with 3 steps

1.1: lithium aluminium tetrahydride / 12 h / 0 - 20 °C

2.1: 1,4-dioxane / 0.17 h / 20 °C

2.2: 12 h

3.1: acetic acid / 2 h / 120 °C / Microwave irradiation

With lithium aluminium tetrahydride; In 1,4-dioxane; acetic acid;

DOI:10.1016/j.bmcl.2014.04.063

upstream raw materials:

2-fluoro-4-(trifluoromethyl)benzonitrile

C₁₀H₁₂F₃NO

2-ethoxy-4-trifluoromethyl-benzonitrile

(R)-1-phenyl-ethyl-amine