1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine

Base Information

• Chemical Name: 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine
• CAS No.: 239100-93-7
• Molecular Formula: C₂₀H₂₉N₃O₄
• Molecular Weight: 375.468
• Mol file: 239100-93-7.mol

Synonyms:1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine

Chemical Property of 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine

There total 2 articles about 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

2-phenyl-1-(piperazin-1-yl)ethanone (88372-33-2) + 3-(tert-butyloxycarbonylamino)propionic acid (3303-84-2) → 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine (239100-93-7)

Guidance literature:

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; at 0 - 20 ℃;

DOI:10.1016/S0968-0896(99)00017-6

Reference yield:

phenylacetic acid (103-82-2) → 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine (239100-93-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: HOBt; DCC / CHCl₃; dimethylformamide / 0.5 h / 20 °C

1.2: 75 percent / CHCl₃; dimethylformamide / 2 h / 20 °C

2.1: 59 percent / HOBt; DIEA; DCC / CH₂Cl₂ / 0 - 20 °C

With benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In dichloromethane; chloroform; N,N-dimethyl-formamide; 1.1: Acylation / 1.2: Acylation / 2.1: Acylation;

DOI:10.1016/S0968-0896(99)00017-6

Reference yield: 90.0%

trifluoroacetic acid (76-05-1) + 1-phenylacetyl-4-[3-(tert-butoxycarbonylamino)propionyl]piperazine (239100-93-7) → 3-amino-1-(4-phenylacetyl-piperazin-1-yl)-propan-1-one; compound with trifluoro-acetic acid

Guidance literature:

In dichloromethane; for 1h;

DOI:10.1016/S0968-0896(99)00017-6

upstream raw materials:

2-phenyl-1-(piperazin-1-yl)ethanone

3-(tert-butyloxycarbonylamino)propionic acid

phenylacetic acid