p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide

Base Information

• Chemical Name: p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide
• CAS No.: 79634-04-1
• Molecular Formula: C₁₅H₁₄BrClN₂O₇S
• Molecular Weight: 481.708
• Mol file: 79634-04-1.mol

Synonyms:p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide

Chemical Property of p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide

There total 2 articles about p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate (79634-02-9) → p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide (79634-04-1)

Guidance literature:

With potassium permanganate; acetic acid;

DOI:10.1021/jm00144a034

Reference yield:

6α-bromopenicillanic acid 1-oxide potassium salt (79886-08-1) → p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate 1,1-dioxide (79634-04-1)

Guidance literature:

Multi-step reaction with 3 steps

1: 70 percent / N,N-dimethyl-acetamide / 24 h / 23 °C

2: 65 percent / quinoline, benzoyl chloride / dioxane / 4 h / Heating

3: 87 percent / aq. KMnO₄, CH₃COOH

With quinoline; potassium permanganate; benzoyl chloride; acetic acid; In 1,4-dioxane; N,N-dimethyl acetamide;

DOI:10.1021/jm00144a034

upstream raw materials:

p-nitrobenzoyl 2β-(chloromethyl)-2α-methyl-6α-bromopenem-3α-carboxylate

6α-bromopenicillanic acid 1-oxide potassium salt