ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

Base Information

Chemical Name:ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate
CAS No.:1616493-23-2
Molecular Formula:C₁₈H₁₄Cl₃FN₂O₃
Molecular Weight:431.678
Hs Code.:

Synonyms:ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

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Chemical Property of ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

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Technology Process of ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

There total 1 articles about ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 138998-49-9
ethyl 2-[(2,6-dichloro-3-pyridinyl)carbonyl]-3-(dimethylamino)-2-propenoate

: 72235-55-3
(3-chloro-2-fluorophenyl)methanamine

: 1616493-23-2
ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

Guidance literature:: In diethyl ether; ethanol; at 20 ℃; for 2h;
DOI:10.1021/jm500340h

Reference yield: 96.0%

: 1616493-23-2
ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

: 1616493-36-7
ethyl 7-chloro-1-(3-chloro-2-fluorobenzyl)-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;
DOI:10.1021/jm500340h

Reference yield:

: 1616493-23-2
ethyl 3-[(3-chloro-2-fluorobenzyl)amino]-2-[(2,6-dichloropyridin-3-yl)carbonyl]acrylate

: 1-(3-chloro-2-fluorobenzyl)-4-oxo-7-(4-pyridin-2-ylpiperazin-1-yl)-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 4 h / 60 °C

2.1: N,N-dimethyl-formamide / 6 h / 80 °C

3.1: sodium hydroxide / 11 h / Reflux

3.2: 0.5 h / Reflux

With potassium carbonate; sodium hydroxide; In N,N-dimethyl-formamide;
DOI:10.1021/jm500340h