2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

Base Information

Chemical Name:2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide
CAS No.:1042275-05-7
Molecular Formula:Br*C₁₂H₁₁N₄O₃
Molecular Weight:339.148
Hs Code.:

Synonyms:2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

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Technology Process of 2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

There total 1 articles about 2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 109-12-6
2-aminopyrimidine

: 99-81-0
4-Nitrophenacyl bromide

: 1042275-05-7
2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

Guidance literature:: With dmap; In acetonitrile; at 20 ℃; for 5h;
DOI:10.1016/j.ejmech.2013.12.034

Reference yield: 83.0%

: 1042275-05-7
2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

: 60472-21-1
[4-(4-nitrophenyl)-1H-imidazol-2-yl]amine

Guidance literature:: With hydrazine hydrate; In acetonitrile; at 100 ℃; for 0.166667h;
DOI:10.1021/jo8008758

Reference yield:

: 1042275-05-7
2-hydroxy-2-(4-nitrophenyl)-2,3-dihydro-1H-imidazo[1,2-a]pyrimidin-4-ium bromide

: 1574306-28-7
tert-butyl (R)-2-amino-4-(4-(1-(tert-butoxycarbonyl)pyrrolidine-2-carboxamido)phenyl)-1H-imidazole-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethyl [2]alcohol / 0.67 h / 120 °C / Microwave irradiation

2.1: methanol / 3 h / 20 °C

3.1: palladium on activated charcoal; hydrogen / tetrahydrofuran / 5 h / 20 °C

4.1: O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; 4-methyl-morpholine / dichloromethane / 0.5 h / 20 °C

4.2: 24 h / 35 °C

With 4-methyl-morpholine; palladium on activated charcoal; hydrogen; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; hydrazine hydrate; In tetrahydrofuran; methanol; dichloromethane; ethyl [2]alcohol;
DOI:10.1016/j.ejmech.2013.12.034