5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine

Base Information

• Chemical Name: 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine
• CAS No.: 137834-58-3
• Molecular Formula: C₄₀H₃₂N₂O₂
• Molecular Weight: 572.706

Synonyms:5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine

Chemical Property of 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine

Chemical Property:

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Technology Process of 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine

There total 9 articles about 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

ethyl 2-methyl-α,5-bis<(triphenylphosphoranylidene)amino>cinnamate (137834-51-6) + diphenyl ketene (525-06-4) → 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine (137834-58-3)

Guidance literature:

In toluene; 1) room temperature, 1 h, 2) 160 deg C, 24 h;

DOI:10.1021/jo00051a007

Reference yield:

C44H37N2O2P (137834-61-8) + diphenyl ketene (525-06-4) → 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine (137834-58-3)

Guidance literature:

at 160 - 170 ℃; Yield given;

DOI:10.1016/S0040-4039(00)92391-8

Reference yield:

3-(hydroxymethyl)-4-methylaniline (111437-10-6) → 5-(ethoxycarbonyl)-7-methyl-3,3-diphenyl-2-(diphenylmethyl)benzo<1,6>naphthyridine (137834-58-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 1) H₂SO₄, NaNO₂, 2) NaN₃ / 1) H₂O, 0 deg C, 30 min, 2) 3 h

2: pyridinium chlorochromate / CH₂Cl₂ / 4 h / Ambient temperature

3: 67 percent / Na, EtOH / 5 h / -15 °C

4: 91 percent / diethyl ether / 12 h / Ambient temperature

5: 93 percent / toluene / 1) room temperature, 1 h, 2) 160 deg C, 24 h

With sodium azide; ethanol; sulfuric acid; sodium; pyridinium chlorochromate; sodium nitrite; In diethyl ether; dichloromethane; toluene;

DOI:10.1021/jo00051a007

upstream raw materials:

C₄₄H₃₇N₂O₂P

diphenyl ketene

ethyl 2-methyl-α,5-bis<(triphenylphosphoranylidene)amino>cinnamate

3-(hydroxymethyl)-4-methylaniline

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