Chemical Property of cyclo[OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-D-Val-OAla-Val-D-OVal-Val]
Chemical Property:
- Appearance/Colour:White solid.
- Vapor Pressure:0mmHg at 25°C
- Melting Point:186-190 °C
- Refractive Index:1.448
- Boiling Point:1321.6 °C at 760 mmHg
- PKA:11.32±0.70(Predicted)
- Flash Point:753.1 °C
- PSA：332.40000
- Density:1.060
- LogP:4.31610
- Storage Temp.:2-8°C
- Solubility.:DMSO: ≥10 mg/mL
- Water Solubility.:Soluble in DMSO at 10mg/ml. Insoluble in water
- XLogP3:9.1
- Hydrogen Bond Donor Count:6
- Hydrogen Bond Acceptor Count:18
- Rotatable Bond Count:9
- Exact Mass:1110.63116004
- Heavy Atom Count:78
- Complexity:1910
- Transport DOT Label:Poison
- Purity/Quality:
-
≥98% *data from raw suppliers
Valinomycin *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn,T,T+,Xi
- Statements:
27/28-36/37/38-21/22
- Safety Statements:
36-45-36/37-28-37/39-26
- MSDS Files:
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SDS file from LookChem
Total 1 MSDS from other Authors
Useful:
- Canonical SMILES:CC1C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)OC(C(=O)NC(C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
- Isomeric SMILES:C[C@H]1C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@@H](C(=O)O[C@H](C(=O)N[C@H](C(=O)O[C@@H](C(=O)N[C@H](C(=O)O1)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C)C)C(C)C)C(C)C)C(C)C
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Description
Valinomycin (2001-95-8) is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 Valinomycin can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3
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Uses
Insecticide, nematocide, Patterson, Wright, US 3520973 (1970 to Am. Cyanamid). antibiotic; LD50 (rat, po) 4 mg/kg K+-selective ionophoric cyclodepsipeptide; potassium ionophore which uncouples oxidative phosphorylation, induces apoptosis in murine thymocytes, inhibits NGF-induced neuronal differentiation and anta
gonizes ET-induced vasoconstriction. Used as insecticide, nematocide. Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumour activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux. Valinomycin is a hydrophobic cyclodepsipeptide with potent antitumor activity. Valinomycin is a highly selective potassium ionophore and this action leads to a diverse range of profound cell membrane effects. More recently, valinomycin has found application as a biosensor to detect to detect potassium efflux.
