Base Information
- Chemical Name:Verdamicin
- CAS No.:49863-48-1
- Molecular Formula:C20H39N5O7
- Molecular Weight:461.553
- Hs Code.:
- Wikipedia:Verdamicin
- Mol file:49863-48-1.mol
Synonyms:verdamicin
Synonyms:verdamicin
99% *data from raw suppliers
VERDAMICIN 95.00% *data from reagent suppliers
The research investigates the biotransformation of sisomicin and verdamicin by Micromonospora sagamiensis. The study found that the resting cells of a 2-deoxystreptamine idiotrophic mutant of M. sagamiensis could transform sisomicin into gentamicin CIa and sagamicin, while verdamicin was transformed into gentamicin C2a, C2, and then CI. The biotransformation products were isolated using ion exchange and carbon column chromatographic procedures and identified through various analytical techniques. The study also compared the biotransformation capabilities of other Micromonospora species, such as M. zionensis and M. inyoensis, and found that they lacked the (4',5')-reduction activity present in M. sagamiensis. Instead, M. zionensis transformed sisomicin into antibiotic G-52 and verdamicin into a new antibiotic, VF3-1, which was suggested to be 6'-N-methylverdamicin based on chromatographic and mass spectrum data. The findings provide insights into the biosynthetic pathways of these antibiotics and their potential for further development.
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