[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

Base Information

Chemical Name:[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid
CAS No.:748746-39-6
Molecular Formula:C₃₄H₄₀N₄O₆
Molecular Weight:600.715
Hs Code.:

[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

Synonyms:[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

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Chemical Property of [(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

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Technology Process of [(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

There total 6 articles about [(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 746582-15-0
[(4'-{(R)-3-[3-((R)-2-Benzyloxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid benzyl ester

: 748746-39-6
[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

Guidance literature:: With hydrogen; palladium on activated charcoal; In water; acetonitrile; for 24h; under 2068.6 Torr; Ambient temperature;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145485-77-4
3-t-butoxy-carbonylamino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-1-benzazepin-3(R)-yl]-butanamide

: 748746-39-6
[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 6 steps

1: 84 percent / CF₃COOH / CH₂Cl₂ / 1 h / Ambient temperature

2: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

3: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

4: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

5: 63 percent / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

6: 71 percent / H₂ / Pd/C / acetonitrile; H₂O / 24 h / 2068.6 Torr / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.19970800421

Reference yield:

: 145486-32-4
3-amino-3-methyl-N-[2,3,4,5-tetrahydro-2-oxo-1H-benzazepin-3(R)-yl]butanamide

: 748746-39-6
[(4'-{(R)-3-[3-((R)-2-Hydroxy-propylamino)-3-methyl-butyrylamino]-2-oxo-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl}-biphenyl-2-carbonyl)-amino]-acetic acid

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 3-Angstroem molecular sieves, 2.) NaBH₃CN / 1.) methanol, pH 6, 2 h, r.t., 2.) methanol/THF, 72 h, r.t.

2: 92 percent / NaH / dimethylformamide / 1.5 h / Ambient temperature

3: 98 percent / CF₃COOH/anisole / CH₂Cl₂ / 1.5 h / Ambient temperature

4: 63 percent / PyBOP / CH₂Cl₂ / 2 h / Ambient temperature

5: 71 percent / H₂ / Pd/C / acetonitrile; H₂O / 24 h / 2068.6 Torr / Ambient temperature

With 3 A molecular sieve; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; hydrogen; sodium hydride; sodium cyanoborohydride; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1002/hlca.19970800421