2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Base Information

Chemical Name:2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate
CAS No.:145220-95-7
Molecular Formula:C₁₉H₁₇N₃O₇
Molecular Weight:399.36
Hs Code.:

Synonyms:2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

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Chemical Property of 2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

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Technology Process of 2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

There total 10 articles about 2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.5%

: 145220-94-6
2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-5-carboxylate

: 145220-95-7
2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Guidance literature:: With manganese(IV) oxide; In dichloromethane; for 2h; Ambient temperature;
DOI:10.1248/cpb.40.1799

Reference yield:

: 60705-25-1
4,4-dimethoxy-3-oxo-butyric acid methyl ester

: 145220-95-7
2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: morpholine, AcOH

2: 100 percent / 3 h / 70 - 120 °C

3: 67 percent / 6 N HCl / acetone / 6 h / Ambient temperature

4: NH₂OH*HCl, NaOAc / acetic acid / 1 h / Ambient temperature

5: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 97-105 deg C, 4.5 h

6: 87.1 percent / 98percent HCO₂H / 5 h / Ambient temperature

7: 80.9 percent / K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

8: 100 percent / NaBH₄ / tetrahydrofuran / 1.5 h

9: 72.5 percent / MnO₂ / CH₂Cl₂ / 2 h / Ambient temperature

With morpholine; hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; formic acid; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.40.1799

Reference yield:

: 99-61-6
3-nitro-benzaldehyde

: 145220-95-7
2-hydroxypropyl 2-cyano-3-methoxycarbonyl-6-methyl-4-(3-nitrophenyl)pyridine-5-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1: morpholine, AcOH

2: 100 percent / 3 h / 70 - 120 °C

3: 67 percent / 6 N HCl / acetone / 6 h / Ambient temperature

4: NH₂OH*HCl, NaOAc / acetic acid / 1 h / Ambient temperature

5: Ac₂O / acetic acid / 1.) RT, 1 h, 2.) 97-105 deg C, 4.5 h

6: 87.1 percent / 98percent HCO₂H / 5 h / Ambient temperature

7: 80.9 percent / K₂CO₃ / dimethylformamide / 1.5 h / Ambient temperature

8: 100 percent / NaBH₄ / tetrahydrofuran / 1.5 h

9: 72.5 percent / MnO₂ / CH₂Cl₂ / 2 h / Ambient temperature

With morpholine; hydrogenchloride; manganese(IV) oxide; sodium tetrahydroborate; formic acid; hydroxylamine hydrochloride; sodium acetate; acetic anhydride; potassium carbonate; acetic acid; In tetrahydrofuran; dichloromethane; acetic acid; N,N-dimethyl-formamide; acetone;
DOI:10.1248/cpb.40.1799