Technology Process of methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate
There total 10 articles about methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium carbonate;
tetrakis(triphenylphosphine) palladium(0);
In
water; toluene;
at 100 ℃;
for 17h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: sulfuric acid / tetrahydrofuran / 12 h / 55 °C
2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C
3.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere
4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere
5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 17 h / 20 °C
6.2: 1 h / 20 °C
7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; toluene / 17 h / 100 °C / Inert atmosphere
With
N-Bromosuccinimide; oxalyl dichloride; sulfuric acid; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere
2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere
3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C
4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 17 h / 20 °C
4.2: 1 h / 20 °C
5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium(0) / water; toluene / 17 h / 100 °C / Inert atmosphere
With
oxalyl dichloride; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid;
tetrakis(triphenylphosphine) palladium(0);
In
1-methyl-pyrrolidin-2-one; dichloromethane; water; 1,2-dichloro-ethane; toluene;
