methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

Base Information

Chemical Name:methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate
CAS No.:1269508-49-7
Molecular Formula:C₃₃H₂₈N₂O₅
Molecular Weight:532.596
Hs Code.:

Synonyms:methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

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Chemical Property of methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

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Technology Process of methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

There total 10 articles about methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 1202889-62-0
methyl 6-cyano-7-(4-(3-iodophenylcarbamoyl)phenoxy)chroman-4-carboxylate

: 183158-34-1
2,3-dimethylphenylboronic acid

: 1269508-49-7
methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In water; toluene; at 100 ℃; for 17h; Inert atmosphere;

Reference yield:

: 1202889-73-3
7-fluoro-3,4-dihydro-2H-chromene-4-carboxylic acid

: 1269508-49-7
methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

Guidance literature:: Multi-step reaction with 7 steps

1.1: sulfuric acid / tetrahydrofuran / 12 h / 55 °C

2.1: N-Bromosuccinimide / N,N-dimethyl-formamide / 2.5 h / 50 °C

3.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere

4.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere

5.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

6.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 17 h / 20 °C

6.2: 1 h / 20 °C

7.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 17 h / 100 °C / Inert atmosphere

With N-Bromosuccinimide; oxalyl dichloride; sulfuric acid; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; dichloromethane; water; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene;

Reference yield:

: 1202889-75-5
methyl 6-bromo-7-fluoro-3,4-dihydro-2H-chromene-4-carboxylate

: 1269508-49-7
methyl 6-cyano-7-(4-(2',3'-dimethylbiphenyl-3-ylcarbamoyl)phenoxy)chroman-4-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: 1-methyl-pyrrolidin-2-one / 6 h / 160 °C / Inert atmosphere

2.1: potassium carbonate / 1-methyl-pyrrolidin-2-one / 18 h / 115 °C / Molecular sieve; Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 1.5 h / 20 °C

4.1: oxalyl dichloride; N,N-dimethyl-formamide / dichloromethane; 1,2-dichloro-ethane / 17 h / 20 °C

4.2: 1 h / 20 °C

5.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / water; toluene / 17 h / 100 °C / Inert atmosphere

With oxalyl dichloride; sodium carbonate; potassium carbonate; N,N-dimethyl-formamide; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1-methyl-pyrrolidin-2-one; dichloromethane; water; 1,2-dichloro-ethane; toluene;