4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

Base Information

Chemical Name:4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate
CAS No.:1443687-79-3
Molecular Formula:C₃₅H₅₄N₄O₄
Molecular Weight:594.838
Hs Code.:

Synonyms:4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

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Chemical Property of 4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

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Technology Process of 4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

There total 5 articles about 4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 112-38-9
10-undecenoic acid

: 1443687-78-2
1-(4-hydroxyphenyl)-3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)urea

: 1443687-79-3
4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In chloroform; for 15h; Reflux;
DOI:10.1039/c2ra22715k

Reference yield:

: 112-64-1
tetradecanoyl chloride

: 1443687-79-3
4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: triethylamine / acetonitrile / 2.25 h / 0 - 10 °C

1.2: 16 h / 20 °C

2.1: potassium tert-butylate / ethanol / 72 h / Reflux

3.1: triethylamine / tetrahydrofuran / 18 h / Reflux

4.1: boron tribromide / dichloromethane / 20 h / -78 - 20 °C

5.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / chloroform / 15 h / Reflux

With dmap; potassium tert-butylate; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; chloroform; acetonitrile;
DOI:10.1039/c2ra22715k

Reference yield:

: 2-amino-4-hydroxy-6-tridecylpyrimidine

: 1443687-79-3
4-(3-(4-oxo-6-tridecyl-1,4-dihydropyrimidin-2-yl)ureido)phenylundec-10-enoate

Guidance literature:: Multi-step reaction with 3 steps

1: triethylamine / tetrahydrofuran / 18 h / Reflux

2: boron tribromide / dichloromethane / 20 h / -78 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; dmap / chloroform / 15 h / Reflux

With dmap; boron tribromide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1039/c2ra22715k