N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide

Base Information

• Chemical Name: N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide
• CAS No.: 1414349-59-9
• Molecular Formula: C₁₇H₁₄F₃NO₂
• Molecular Weight: 321.299
• Mol file: 1414349-59-9.mol

Synonyms:N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide

Chemical Property of N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide

There total 2 articles about N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-tolylacetic acid (622-47-9) + 3-trifluoromethylphenyl isonitrile → N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide (1414349-59-9)

Guidance literature:

In toluene; at 110 ℃; Sealed tube; Inert atmosphere;

DOI:10.1016/j.tet.2012.09.068

Reference yield:

N-(3-(trifluoromethyl)phenyl)formamide (657-78-3) → N-formyl-2-(p-tolyl)-N-(3-(trifluoromethyl)phenyl)acetamide (1414349-59-9)

Guidance literature:

Multi-step reaction with 2 steps

1: diisopropylamine; trichlorophosphate / dichloromethane / 0.33 h / 0 - 20 °C / Inert atmosphere

2: toluene / 110 °C / Sealed tube; Inert atmosphere

With diisopropylamine; trichlorophosphate; In dichloromethane; toluene;

DOI:10.1016/j.tet.2012.09.068

upstream raw materials:

4-tolylacetic acid

N-(3-(trifluoromethyl)phenyl)formamide