(3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester

Base Information

Chemical Name:(3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester
CAS No.:57103-62-5
Molecular Formula:C₂₈H₃₇NO₆
Molecular Weight:483.605
Hs Code.:

Synonyms:(3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester

Chemical Property:

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Technology Process of (3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester

There total 5 articles about (3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 56774-66-4
2-(benzyloxy)-3,4-dimethoxyphenacyl bromide

: 56246-53-8
(+)-ethyl cincholoiponate

: 57103-62-5
(3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester

Guidance literature:: With potassium carbonate; In benzene; 1.) room temperature, 8 h, 2.) 50 deg C, 2 h;
DOI:10.1021/jo01298a025

Reference yield:

: 56774-66-4
2-(benzyloxy)-3,4-dimethoxyphenacyl bromide

: 26599-66-6,35167-69-2,56246-53-8,57968-43-1
(+/-)-trans-3-ethyl-4-piperidineacetic acid ethyl ester

: 57103-62-5,109785-66-2
(+/-)-trans-1-(2-benzyloxy-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic acid ethyl ester

Guidance literature:: With potassium carbonate; In benzene; at 50 ℃; for 2h; Yield given;
DOI:10.1248/cpb.34.496

Reference yield:

: 474964-21-1
cinchonine

: 57103-62-5
(3R,4S)-(-)-(2-(Benzyloxy)-3,4-dimethoxyphenacyl)-3-ethyl-4-piperidineacetic Acid Ethyl Ester

Guidance literature:: Multi-step reaction with 2 steps

1: 50 percent

2: 91 percent / K₂CO₃ / benzene / 1.) room temperature, 8 h, 2.) 50 deg C, 2 h

With potassium carbonate; In benzene;
DOI:10.1021/jo01298a025