benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Base Information

Chemical Name:benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester
CAS No.:753487-86-4
Molecular Formula:C₆₂H₇₉N₅O₁₀Si
Molecular Weight:1082.42
Hs Code.:

benzoic acid 4-({3-(<i>tert</i>-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1<i>H</i>-indol-3-yl]-2-[2-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Synonyms:benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Suppliers and Price of benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

There total 21 articles about benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 753487-73-9
C₆₅H₈₃N₅O₁₀Si

: 753487-86-4
benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-methylaniline; In tetrahydrofuran;
DOI:10.1016/j.tet.2005.03.058

Reference yield:

: 753487-47-7
Benzoic acid (2R,4S)-4-(tert-butoxycarbonyl-methyl-amino)-4-carboxy-2-methyl-butyl ester

: 753487-86-4
benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 79 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / CH₂Cl₂ / 0 - 20 °C

2: trifluoroacetic acid / 0 - 20 °C

3: 70 percent / Bis(2-oxo-3-oxazolidinyl)phosphonic chloride; diisopropylethylamine / 0 °C

4: piperidine

5: 72 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / 0 °C

6: 100 percent / PhNHMe; Pd(PPh₃)4 / tetrahydrofuran

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N-methylaniline; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tet.2005.03.058

Reference yield:

: 855315-80-9
Benzoic acid (2R,4S)-4-((S)-1-allyloxycarbonyl-ethylcarbamoyl)-2-methyl-4-methylamino-butyl ester

: 753487-86-4
benzoic acid 4-({3-(tert-butyl-dimethyl-silanyloxy)-3-[1-(1,1-dimethyl-allyl)-1H-indol-3-yl]-2-[2-(9H-fluoren-9-ylmethoxycarbonylamino)-3,5-dimethyl-hex-4-enoylamino]-propionyl}-methyl-amino)-4-(1-carboxy-ethylcarbamoyl)-2-methyl-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 70 percent / Bis(2-oxo-3-oxazolidinyl)phosphonic chloride; diisopropylethylamine / 0 °C

2: piperidine

3: 72 percent / 1-hydroxybenzotriazole hydrate; 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride; diisopropylethylamine / 0 °C

4: 100 percent / PhNHMe; Pd(PPh₃)4 / tetrahydrofuran

With piperidine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; bis-(2-oxo-3-oxazolidinyl)phosphoryl chloride; 1-hydroxybenzotriazol-hydrate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; N-methylaniline; In tetrahydrofuran;
DOI:10.1016/j.tet.2005.03.058