<5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone

Base Information

• Chemical Name: <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone
• CAS No.: 103068-63-9
• Molecular Formula: C₁₅H₁₇FN₄O
• Molecular Weight: 288.325

Synonyms:<5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone

Chemical Property of <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

SDS file from LookChem

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Technology Process of <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone

There total 3 articles about <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

5-<<(dimethylamino)methylene>amino>-α-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-methanol (103068-62-8) → <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone (103068-63-9)

Guidance literature:

With jones reagent; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1021/jm00159a011

Reference yield:

o-fluorobromobenzene (1072-85-1) → <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone (103068-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 15 min, 2.) THF, from -70 deg C to RT, 18 h

2: 43 percent / Jones reagent / CH₂Cl₂ / 0.33 h / 0 °C

With n-butyllithium; jones reagent; In dichloromethane;

DOI:10.1021/jm00159a011

Reference yield:

5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde (103068-61-7) → <5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazol-4-yl>(2-fluorophenyl)methanone (103068-63-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-BuLi / 1.) THF, hexane, -70 deg C, 15 min, 2.) THF, from -70 deg C to RT, 18 h

2: 43 percent / Jones reagent / CH₂Cl₂ / 0.33 h / 0 °C

With n-butyllithium; jones reagent; In dichloromethane;

DOI:10.1021/jm00159a011

upstream raw materials:

5-<<(dimethylamino)methylene>amino>-α-(2-fluorophenyl)-1,3-dimethyl-1H-pyrazole-4-methanol

o-fluorobromobenzene

5-<<(dimethylamino)methylene>amino>-1,3-dimethyl-1H-pyrazole-4-carboxaldehyde

Downstream raw materials:

2-bromo-N-<4-(2-fluorobenzoyl)-1,3-dimethyl-1H-pyrazol-5-yl>acetamide

N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-(4-phenyl-piperidin-1-yl)-acetamide

N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-{methyl-[3-(2-methyl-piperidin-1-yl)-propyl]-amino}-acetamide

N-[4-(2-Fluoro-benzoyl)-2,5-dimethyl-2H-pyrazol-3-yl]-2-[3-(4-methyl-piperidin-1-yl)-propylamino]-acetamide

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