(R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one

Base Information

• Chemical Name: (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one
• CAS No.: 1398566-69-2
• Molecular Formula: C₁₆H₁₂Cl₂N₂O₃
• Molecular Weight: 351.189
• Mol file: 1398566-69-2.mol

Synonyms:(R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one

Chemical Property of (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one

Chemical Property:

Purity/Quality:

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Technology Process of (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one

There total 3 articles about (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

→ (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one (1398566-69-2) + (S)--3,4-dichloro-3-((R)-2-nitro-1-phenylethyl)indolin-2-one

Guidance literature:

With C₄₉H₃₇F₆N₃O₂; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

(2-nitroethenyl)benzene (102-96-5) + dichloro-3,4 indolinone-2 (77484-21-0) → (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one (1398566-69-2) + (S)--3,4-dichloro-3-((R)-2-nitro-1-phenylethyl)indolin-2-one + C16H12Cl2N2O3

Guidance literature:

With C₄₉H₃₅F₆N₃O₂; In dichloromethane; at 20 ℃; for 24h; Overall yield = 80%;

DOI:10.1002/bkcs.10264

Reference yield:

nitrostyrene (5153-67-3) + dichloro-3,4 indolinone-2 (77484-21-0) → (R)--3,4-dichloro-3-((S)-2-nitro-1-phenylethyl)indolin-2-one (1398566-69-2) + (S)--3,4-dichloro-3-((R)-2-nitro-1-phenylethyl)indolin-2-one + C16H12Cl2N2O3

Guidance literature:

With C₃₂H₃₀F₆N₄O₃; In chloroform; at 4 ℃; Overall yield = 99 %; Overall yield = 35 mg;

DOI:10.1021/ol302245b DOI:10.1021/ol302245b

upstream raw materials:

nitrostyrene

dichloro-3,4 indolinone-2

(2-nitroethenyl)benzene