4-(3-hydroxypropyl)benzyl bromide

Base Information

• Chemical Name: 4-(3-hydroxypropyl)benzyl bromide
• CAS No.: 141222-24-4
• Molecular Formula: C₁₀H₁₃BrO
• Molecular Weight: 229.117
• Mol file: 141222-24-4.mol

Synonyms:4-(3-hydroxypropyl)benzyl bromide

Chemical Property of 4-(3-hydroxypropyl)benzyl bromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of 4-(3-hydroxypropyl)benzyl bromide

There total 1 articles about 4-(3-hydroxypropyl)benzyl bromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-<4-(hydroxymethyl)phenyl>propanol (38628-53-4) → 4-(3-hydroxypropyl)benzyl bromide (141222-24-4)

Guidance literature:

With hydrogen bromide; In diethyl ether; for 1h; Ambient temperature;

DOI:10.1021/jm00088a004

Reference yield:

4-(3-hydroxypropyl)benzyl bromide (141222-24-4) → (S)-5-((S)-1-tert-Butoxycarbonylamino-2-phenyl-ethyl)-3-[4-(3-hydroxy-propyl)-benzyl]-2-oxo-tetrahydro-furan-3-carboxylic acid

Guidance literature:

Multi-step reaction with 2 steps

1: NaOEt / ethanol / 18 h / Ambient temperature

2: aq. LiOH / ethanol / 5 h

With lithium hydroxide; sodium ethanolate; In ethanol;

DOI:10.1021/jm00088a004

Reference yield:

4-(3-hydroxypropyl)benzyl bromide (141222-24-4) → N-<(1,1-dimethylethoxy)carbonyl>-5(S)-amino-4(S)-<<(1,1'-dimethylethyl)dimethylsilyl>oxy>-6-phenyl-2(R)-<<4-<3-<<(1',1'-dimethylethyl)dimethylsilyl>oxy>propyl>phenyl>methyl>hexanoic acid

Guidance literature:

Multi-step reaction with 5 steps

1: NaOEt / ethanol / 18 h / Ambient temperature

2: aq. LiOH / ethanol / 5 h

3: toluene / 24 h / Heating

4: aq. LiOH / 1,2-dimethoxy-ethane / 24 h / Ambient temperature

5: 1.) imidazole / 1.) DMF, RT, 24 h, 2.) DMF, MeOH, RT, 4 h

With 1H-imidazole; lithium hydroxide; sodium ethanolate; In 1,2-dimethoxyethane; ethanol; toluene;

DOI:10.1021/jm00088a004

upstream raw materials:

3-<4-(hydroxymethyl)phenyl>propanol

Downstream raw materials:

((S)-1-{(2S,4R)-4-[4-(3-Hydroxy-propyl)-benzyl]-5-oxo-tetrahydro-furan-2-yl}-2-phenyl-ethyl)-carbamic acid tert-butyl ester

L-693,549

Refernces