<2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

Base Information

Chemical Name:<2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide
CAS No.:203922-05-8
Molecular Formula:C₂₂H₂₂ClF₃N₂O₂
Molecular Weight:438.877
Hs Code.:

Synonyms:<2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

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Chemical Property of <2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

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Technology Process of <2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

There total 5 articles about <2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 203921-99-7
<2-(1H-indol-4-yloxy)ethyl>(4-phenylbutyl)trifluoroacetamide

: 203922-05-8
<2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

Guidance literature:: With N-chloro-succinimide; In tetrahydrofuran; for 3h; Ambient temperature;
DOI:10.1021/jm990023s

Reference yield:

: 2380-94-1
1H-indol-4-ol

: 203922-05-8
<2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

Guidance literature:: Multi-step reaction with 4 steps

1: 57 percent / Ph₃P, DEAD / tetrahydrofuran / 16 h / Ambient temperature

2: 66 percent / dimethylsulfoxide / 6 h / 80 °C

3: 52 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

4: 71 percent / NCS / tetrahydrofuran / 3 h / Ambient temperature

With N-chloro-succinimide; triethylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm990023s

Reference yield:

: 180161-01-7
2-(1H-Indol-4-yloxy)-chloroethane

: 203922-05-8
<2-(3-chloro-1H-indol-4-yloxy)ethyl>-(4-phenylbutyl)trifluoroacetamide

Guidance literature:: Multi-step reaction with 3 steps

1: 66 percent / dimethylsulfoxide / 6 h / 80 °C

2: 52 percent / Et₃N / CH₂Cl₂ / 1 h / Ambient temperature

3: 71 percent / NCS / tetrahydrofuran / 3 h / Ambient temperature

With N-chloro-succinimide; triethylamine; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1021/jm990023s