1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Base Information

Chemical Name:1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene
CAS No.:745809-50-1
Molecular Formula:C₁₉H₂₈O₃Si
Molecular Weight:332.515
Hs Code.:

Synonyms:1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Suppliers and Price of 1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

There total 8 articles about 1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 58169-99-6
2,3,4,6-tetrabromo-5-methyl-phenol

: 745809-50-1
1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Guidance literature:: Multi-step reaction with 6 steps

1.1: HI / H₂O / Heating

1.2: 2,6-lutidine

2.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

2.2: 95 percent / tetrahydrofuran; pentane / 0.5 h / 0 °C

3.1: n-BuLi; TMEDA / diethyl ether; hexane; toluene / 0.03 h / -78 °C

3.2: 68 percent / various solvents / 1 h / -78 - 23 °C

4.1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 16 h / 23 °C

5.1: TBAF; HOAc / tetrahydrofuran / 0 - 23 °C

6.1: 148 mg / pyridine / 16 h

With pyridine; 1H-imidazole; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; tetrabutyl ammonium fluoride; hydrogen iodide; tert.-butyl lithium; acetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; pentane;
DOI:10.1021/jo049426c

Reference yield:

: 34946-83-3
2,4,4,6-tetrabromo-3-methyl-cyclohexa-2,5-dienone

: 745809-50-1
1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Guidance literature:: Multi-step reaction with 7 steps

1.1: 57 percent / sulfuric acid / 16 h

2.1: HI / H₂O / Heating

2.2: 2,6-lutidine

3.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

3.2: 95 percent / tetrahydrofuran; pentane / 0.5 h / 0 °C

4.1: n-BuLi; TMEDA / diethyl ether; hexane; toluene / 0.03 h / -78 °C

4.2: 68 percent / various solvents / 1 h / -78 - 23 °C

5.1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 16 h / 23 °C

6.1: TBAF; HOAc / tetrahydrofuran / 0 - 23 °C

7.1: 148 mg / pyridine / 16 h

With pyridine; 1H-imidazole; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen iodide; tert.-butyl lithium; acetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; toluene; pentane;
DOI:10.1021/jo049426c

Reference yield:

: 108-39-4
3-methyl-phenol

: 745809-50-1
1-acetoxy-3-[1-(tert-butyldimethylsilanyloxy)but-3-ynyl]-5-methylbenzene

Guidance literature:: Multi-step reaction with 8 steps

1.1: 52 percent / Br₂ / acetic acid

2.1: 57 percent / sulfuric acid / 16 h

3.1: HI / H₂O / Heating

3.2: 2,6-lutidine

4.1: t-BuLi / tetrahydrofuran; pentane / 1 h / -78 °C

4.2: 95 percent / tetrahydrofuran; pentane / 0.5 h / 0 °C

5.1: n-BuLi; TMEDA / diethyl ether; hexane; toluene / 0.03 h / -78 °C

5.2: 68 percent / various solvents / 1 h / -78 - 23 °C

6.1: 68 percent / imidazole; DMAP / CH₂Cl₂ / 16 h / 23 °C

7.1: TBAF; HOAc / tetrahydrofuran / 0 - 23 °C

8.1: 148 mg / pyridine / 16 h

With pyridine; 1H-imidazole; dmap; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; sulfuric acid; tetrabutyl ammonium fluoride; hydrogen iodide; bromine; tert.-butyl lithium; acetic acid; In tetrahydrofuran; diethyl ether; hexane; dichloromethane; water; acetic acid; toluene; pentane;
DOI:10.1021/jo049426c