N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

Base Information

Chemical Name:N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide
CAS No.:1435387-84-0
Molecular Formula:C₁₈H₁₇N₃O₂S
Molecular Weight:339.418
Hs Code.:

Synonyms:N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

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Chemical Property of N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

Chemical Property:

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Technology Process of N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

There total 8 articles about N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 7463-31-2
3-Acetamidoacetophenone

: 1435387-84-0
N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 6 steps

1: copper(ll) bromide / ethyl acetate / Reflux; Inert atmosphere

2: acetic anhydride; nitric acid / 2 h / 0 - 20 °C / Inert atmosphere

3: acetone / 0.5 h / 20 °C / Inert atmosphere

4: sulfuric acid; acetic acid / 1 h / 100 °C / Inert atmosphere

5: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

6: iron; ammonium chloride / ethanol / 1 h / 80 °C / Inert atmosphere

With pyridine; sulfuric acid; nitric acid; acetic anhydride; iron; ammonium chloride; acetic acid; copper(ll) bromide; In tetrahydrofuran; ethanol; ethyl acetate; acetone;
DOI:10.1021/jm301793a

Reference yield:

: 1435387-52-2
N-(2-nitro-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

: 1435387-84-0
N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

Guidance literature:: With iron; ammonium chloride; In ethanol; at 80 ℃; for 1h; Inert atmosphere;
DOI:10.1021/jm301793a

Reference yield:

: 30095-56-8
1-(3-Acetylaminophenyl)-2-bromoethanone

: 1435387-84-0
N-(2-amino-5-(2-oxo-2,3-dihydrothiazol-4-yl)phenyl)-3-phenylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1: acetic anhydride; nitric acid / 2 h / 0 - 20 °C / Inert atmosphere

2: acetone / 0.5 h / 20 °C / Inert atmosphere

3: sulfuric acid; acetic acid / 1 h / 100 °C / Inert atmosphere

4: pyridine / tetrahydrofuran / 2 h / 20 °C / Inert atmosphere

5: iron; ammonium chloride / ethanol / 1 h / 80 °C / Inert atmosphere

With pyridine; sulfuric acid; nitric acid; acetic anhydride; iron; ammonium chloride; acetic acid; In tetrahydrofuran; ethanol; acetone;
DOI:10.1021/jm301793a