11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

Base Information

Chemical Name:11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one
CAS No.:269742-88-3
Molecular Formula:C₂₂H₁₇NO₂S
Molecular Weight:359.448
Hs Code.:

Synonyms:11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

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Chemical Property of 11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

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Technology Process of 11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

There total 5 articles about 11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 269742-87-2
2-benzenesulfinylmethyl-3-benzyl-3-hydroxy-2,3-dihydro-isoindol-1-one

: 269742-88-3
11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

Guidance literature:: With pyridine; trifluoroacetic anhydride; In dichloromethane; at 20 ℃; for 5h;
DOI:10.1021/ol005545c

Reference yield:

: 17564-64-6
N-(chloromethyl)phthalimide

: 269742-88-3
11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

Guidance literature:: Multi-step reaction with 4 steps

1: 90 percent / sodium methylate / dimethylformamide / 5 h / 20 °C

2: 51 percent / CH₂Cl₂; diethyl ether / 3 h / 20 °C

3: 100 percent / mCPBA / CH₂Cl₂ / 0.03 h / 0 °C

4: 56 percent / trifluoroacetic anhydride; pyridine / CH₂Cl₂ / 5 h / 20 °C

With pyridine; sodium methylate; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: Substitution / 2: Grignard reaction / 3: Oxidation / 4: Dehydration;
DOI:10.1021/ol005545c

Reference yield:

: 32637-30-2
N-(phenylthiomethyl)phthalimide

: 269742-88-3
11b-hydroxy-11b,12-dihydro-5-(phenylthio)-5H-isoindolo[2,1-b]isoquinolin-7-one

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / CH₂Cl₂; diethyl ether / 3 h / 20 °C

2: 100 percent / mCPBA / CH₂Cl₂ / 0.03 h / 0 °C

3: 56 percent / trifluoroacetic anhydride; pyridine / CH₂Cl₂ / 5 h / 20 °C

With pyridine; 3-chloro-benzenecarboperoxoic acid; trifluoroacetic anhydride; In diethyl ether; dichloromethane; 1: Grignard reaction / 2: Oxidation / 3: Dehydration;
DOI:10.1021/ol005545c