(R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

Base Information

Chemical Name:(R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine
CAS No.:1526935-30-7
Molecular Formula:C₂₃H₃₀FNO₄
Molecular Weight:403.494
Hs Code.:

Synonyms:(R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

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Chemical Property of (R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

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Technology Process of (R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

There total 10 articles about (R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₃H₂₈FNO₄

: 1526935-30-7
(R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

Guidance literature:: With sodium tetrahydroborate; In methanol; at 20 ℃;
DOI:10.1021/jm401384w

Reference yield:

: 90-02-8
salicylaldehyde

: 1526935-30-7
(R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / N,N-dimethyl-formamide / 50 °C / Inert atmosphere

2: N-ethyl-N,N-diisopropylamine / methanol / 95 °C / Inert atmosphere

3: sodium tetrahydroborate / methanol / 20 °C

With sodium tetrahydroborate; potassium carbonate; N-ethyl-N,N-diisopropylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm401384w

Reference yield:

: 124439-98-1
(R)-7-hydroxychroman-2-carboxylic acid ethyl ester

: 1526935-30-7
(R)-N-[7-(methoxymethoxy)chroman-2-yl]methyl 2-(4-fluorobutoxy)benzyl amine

Guidance literature:: Multi-step reaction with 7 steps

1: N-ethyl-N,N-diisopropylamine / dichloromethane

2: lithium borohydride / tetrahydrofuran / 2 h / 20 °C / Cooling with ice

3: pyridine / 0 - 4 °C

4: N,N-dimethyl-formamide / 16 h / 80 °C

5: hydrazine hydrate / ethanol / 16 h / 80 °C

6: N-ethyl-N,N-diisopropylamine / methanol / 95 °C / Inert atmosphere

7: sodium tetrahydroborate / methanol / 20 °C

With pyridine; sodium tetrahydroborate; lithium borohydride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; methanol; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm401384w