2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Base Information

Chemical Name:2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one
CAS No.:1312415-19-2
Molecular Formula:C₁₃H₁₀ClFN₂OS
Molecular Weight:296.753
Hs Code.:

Synonyms:2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

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Chemical Property of 2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

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Technology Process of 2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

There total 8 articles about 2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1312415-17-0
C₁₃H₁₁FN₂O₂S

: 1312415-19-2
2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Guidance literature:: With thionyl chloride; In dichloromethane; at 20 ℃; for 2h;

Reference yield:

: 1312412-94-4
3-bromo-1-(4-fluorophenyl)piperidine-2,4-dione

: 1312415-19-2
2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / ethanol / 2 h / 80 °C

2: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

3: thionyl chloride / dichloromethane / 2 h / 20 °C

With methanol; sodium tetrahydroborate; thionyl chloride; sodium hydrogencarbonate; In ethanol; dichloromethane;

Reference yield:

: 1312412-93-3
1-(4-fluorophenyl)-2,4-dioxopiperidine-3-carboxylic acid ethyl ester

: 1312415-19-2
2-chloromethyl-5-(4-fluorophenyl)-6,7-dihydro-5H-thiazolo[5,4-c]pyridin-4-one

Guidance literature:: Multi-step reaction with 5 steps

1: water; acetic acid / 16 h / 90 °C

2: N-Bromosuccinimide / dichloromethane / 0.5 h / 0 °C

3: sodium hydrogencarbonate / ethanol / 2 h / 80 °C

4: sodium tetrahydroborate; methanol / 2 h / 0 - 20 °C

5: thionyl chloride / dichloromethane / 2 h / 20 °C

With methanol; sodium tetrahydroborate; N-Bromosuccinimide; thionyl chloride; water; sodium hydrogencarbonate; acetic acid; In ethanol; dichloromethane;