Technology Process of (E)-7-benzenesulfonyl-3-(2-bromo-ethyl)-2,2-dimethyl-hept-6-enal
There total 11 articles about (E)-7-benzenesulfonyl-3-(2-bromo-ethyl)-2,2-dimethyl-hept-6-enal which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride;
In
dichloromethane;
for 5h;
Reflux;
Inert atmosphere;
DOI:10.1021/ol102961x
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: triethylamine / diethyl ether / -30 - 0 °C
2.1: lithium bromide / acetonitrile / 1 h / Reflux
3.1: diisobutylaluminium hydride / tetrahydrofuran; hexanes / 0 - 20 °C
4.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
4.2: -78 - 20 °C
5.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 5 h / Reflux; Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; lithium bromide;
In
tetrahydrofuran; hexanes; diethyl ether; dichloromethane; acetonitrile;
4.1: Swern oxidation / 4.2: Swern oxidation;
DOI:10.1021/ol102961x
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: lithium bromide / acetonitrile / 1 h / Reflux
2.1: diisobutylaluminium hydride / tetrahydrofuran; hexanes / 0 - 20 °C
3.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / -78 °C
3.2: -78 - 20 °C
4.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 5 h / Reflux; Inert atmosphere
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; oxalyl dichloride; diisobutylaluminium hydride; dimethyl sulfoxide; lithium bromide;
In
tetrahydrofuran; hexanes; dichloromethane; acetonitrile;
3.1: Swern oxidation / 3.2: Swern oxidation;
DOI:10.1021/ol102961x
