(2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

Base Information

Chemical Name:(2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid
CAS No.:578717-59-6
Molecular Formula:C₁₄H₂₅NO₆
Molecular Weight:303.356
Hs Code.:

Synonyms:(2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

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Chemical Property of (2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

Chemical Property:

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Technology Process of (2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

There total 3 articles about (2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: C₉H₁₇NO₄

: 578717-59-6
(2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

Guidance literature:: C₉H₁₇NO₄; With lithium hydroxide; In ethanol; for 2h;

di-tert-butyl dicarbonate; In ethanol; for 2h;

With potassium hydrogensulfate; In ethanol; water; pH=3 - 4;
DOI:10.1016/j.bmc.2011.05.022

Reference yield:

: 1319734-54-7
C₂₁H₃₅NO₅

: 578717-59-6
(2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydrogenchloride / tetrahydrofuran; water

2.1: lithium hydroxide / ethanol / 2 h

2.2: 2 h

2.3: pH 3 - 4

With hydrogenchloride; lithium hydroxide; In tetrahydrofuran; ethanol; water;
DOI:10.1016/j.bmc.2011.05.022

Reference yield:

: 1062608-12-1
C₇H₁₂O₂

: 578717-59-6
(2R,3R)-2-(t-butoxycarbonylamino)-3-hydroxy-3-(4-hydroxycyclohexyl)propanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: tris(ethoxy)monochloro titanium; triethylamine / dichloromethane / 5 h / 0 °C

1.2: Cooling

2.1: hydrogenchloride / tetrahydrofuran; water

3.1: lithium hydroxide / ethanol / 2 h

3.2: 2 h

3.3: pH 3 - 4

With hydrogenchloride; tris(ethoxy)monochloro titanium; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; 1.1: Aldol condensation;
DOI:10.1016/j.bmc.2011.05.022