3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

Base Information

Chemical Name:3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid
CAS No.:1415129-00-8
Molecular Formula:C₃₁H₂₄ClF₆N₃O₃
Molecular Weight:635.993
Hs Code.:

Synonyms:3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

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Chemical Property of 3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

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Technology Process of 3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

There total 12 articles about 3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415130-81-2
ethyl 3-(5-(2-(((2-chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido)propanoate

: 1415129-00-8
3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

Guidance literature:: ethyl 3-(5-(2-(((2-chloro-4'-(trifluoromethyl)-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido)propanoate; With water; sodium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 2h;

With hydrogenchloride; In tetrahydrofuran; methanol; water;

Reference yield:

: 1274070-41-5
Ethyl 3-(5-bromopicolinamido)propanoate

: 1415129-00-8
3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium acetate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane / 1 h / 85 °C

2.1: potassium phosphate monohydrate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane / 10 h / 90 °C

3.1: potassium phosphate monohydrate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane / 10 h / 90 °C

4.1: acetic acid / ethanol / 5 h / 80 °C

4.2: 2 h / 20 °C

5.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With potassium phosphate monohydrate; water; potassium acetate; acetic acid; sodium hydroxide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;

Reference yield:

: 1415129-85-9
ethyl 3-(5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinamido)propanoate

: 1415129-00-8
3-(5-(2-(((2-chloro-4'-(trifluoromethyl-[1,1'-biphenyl]-4-yl)amino)methyl)-3-methyl-5-(trifluoromethyl)phenyl)picolinamido))propanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane / 16 h / 80 - 90 °C

2.1: potassium phosphate monohydrate / [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II) / 1,4-dioxane / 10 h / 90 °C

3.1: acetic acid / ethanol / 5 h / 80 °C

3.2: 2 h / 20 °C

4.1: sodium hydroxide; water / tetrahydrofuran; methanol / 2 h / 20 °C

With potassium phosphate monohydrate; water; potassium carbonate; acetic acid; sodium hydroxide; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); In tetrahydrofuran; 1,4-dioxane; methanol; ethanol;