2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

Base Information

Chemical Name:2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid
CAS No.:1256256-18-4
Molecular Formula:C₃₀H₃₂N₂O₂S
Molecular Weight:484.662
Hs Code.:

Synonyms:2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

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Chemical Property of 2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

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Technology Process of 2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

There total 4 articles about 2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.5%

: 1256254-49-5
ethyl 2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-1,7-diaza-fluoren-3-yl]pentanoate

: 1256256-18-4
2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

Guidance literature:: ethyl 2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-1,7-diaza-fluoren-3-yl]pentanoate; With sodium hydroxide; In methanol; ethanol; for 18h; Reflux;

With hydrogenchloride; In water; pH=2;

Reference yield:

: 712265-71-9
ethyl 2-((2-methyl-1,3-dioxolan-2-yl)methyl)pentanoate

: 1256256-18-4
2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: boron tribromide / hexane; dichloromethane / -78 - -20 °C / Inert atmosphere

2.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube

3.1: sodium hydroxide / methanol; ethanol / 18 h / Reflux

3.2: pH 2

With chloro-trimethyl-silane; boron tribromide; sodium hydroxide; In methanol; ethanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 158038-41-6
ethyl 4-oxo-2-propylpentanoate

: 1256256-18-4
2-[7-benzyl-2-methyl-4-(p-tolyl)-5,6,7,8-tetrahydro-9-thia-l,7-diaza-fluoren-3-yl]pentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: chloro-trimethyl-silane / N,N-dimethyl-formamide / 72 h / 100 °C / Inert atmosphere; Sealed tube

2.1: sodium hydroxide / methanol; ethanol / 18 h / Reflux

2.2: pH 2

With chloro-trimethyl-silane; sodium hydroxide; In methanol; ethanol; N,N-dimethyl-formamide;