2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole

Base Information

• Chemical Name: 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole
• CAS No.: 129012-02-8
• Molecular Formula: C₂₆H₂₅N₅O₂
• Molecular Weight: 439.517
• Mol file: 129012-02-8.mol

Synonyms:2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole

Chemical Property of 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole

There total 3 articles about 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-(4-methoxyphenyl)benzoxazole-6-carboxaldehyde (67563-09-1) + 4-(4-methylpiperazino)-1,2-diaminobenzene (54998-08-2) → 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole (129012-02-8)

Guidance literature:

In nitrobenzene; at 140 - 150 ℃;

Reference yield:

6-hydroxymethyl-2-(4-methoxyphenyl)benzoxazole (127866-83-5) → 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole (129012-02-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 86 percent / pyridinium chlorochromate

2: 90 percent / nitrobenzene / 140 - 150 °C

With pyridinium chlorochromate; In nitrobenzene;

Reference yield:

ethyl 2-(4-methoxyphenyl)benzoxazole-6-carboxylate (127866-82-4) → 2-(4-Methoxy-phenyl)-6-[6-(4-methyl-piperazin-1-yl)-1H-benzoimidazol-2-yl]-benzooxazole (129012-02-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 90 percent / lithium aluminium hydride / diethyl ether; tetrahydrofuran / 12 h / Ambient temperature

2: 86 percent / pyridinium chlorochromate

3: 90 percent / nitrobenzene / 140 - 150 °C

With lithium aluminium tetrahydride; pyridinium chlorochromate; In tetrahydrofuran; diethyl ether; nitrobenzene;

upstream raw materials:

2-(4-methoxyphenyl)benzoxazole-6-carboxaldehyde

4-(4-methylpiperazino)-1,2-diaminobenzene

6-hydroxymethyl-2-(4-methoxyphenyl)benzoxazole

ethyl 2-(4-methoxyphenyl)benzoxazole-6-carboxylate