(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

Base Information

Chemical Name:(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate
CAS No.:1072091-67-8
Molecular Formula:C₃₈H₅₃NO₆Si
Molecular Weight:647.927
Hs Code.:

(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

Synonyms:(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

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Chemical Property of (2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

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Technology Process of (2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

There total 7 articles about (2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoic acid

: 1072091-66-7
(2E,4S)-4-amino-3-methylhepta-2,6-dien-1-yl benzoate hydrochloride

: 1072091-67-8
(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 17.5h;

Reference yield:

: 1072091-52-1
tert-butyl (4S,5S)-4-allyl-2,2,5-trimethyl-1,3-oxazolidine-3-carboxylate

: 1072091-67-8
(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: water / camphor-10-sulfonic acid / methanol / 4 h / 20 °C

2.1: Dess-Martin periodane / dichloromethane / 3.5 h / 20 °C

3.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

3.2: 2.17 h / 0 - 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

4.2: 1 h / -78 °C

4.3: 1 h / 20 °C

5.1: pyridine; dmap / dichloromethane / 8.5 h / 20 °C

6.1: hydrogenchloride / ethyl acetate / 0.67 h / 0 °C

7.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 17.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; boron trifluoride diethyl etherate; water; sodium hydride; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 1072091-49-6
C₁₄H₂₅NO₄

: 1072091-67-8
(2E,4S)-4-({(3R)-3-{[tert-butyl(dimethyl)silyl]oxy}-5-[(2S,4R,5S)-4-methyl-2-phenyl-5-vinyl-1,3-dioxolan-4-yl]pentanoyl}amino)-3-methylhepta-2,6-dien-1-yl benzoate

Guidance literature:: Multi-step reaction with 9 steps

1.1: pyridine; dmap / dichloromethane / 5 h / 20 °C

2.1: sodium formate; triethylamine / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 8 h / 65 °C

3.1: water / camphor-10-sulfonic acid / methanol / 4 h / 20 °C

4.1: Dess-Martin periodane / dichloromethane / 3.5 h / 20 °C

5.1: sodium hydride / tetrahydrofuran / 0.33 h / 0 °C

5.2: 2.17 h / 0 - 20 °C

6.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / -78 °C

6.2: 1 h / -78 °C

6.3: 1 h / 20 °C

7.1: pyridine; dmap / dichloromethane / 8.5 h / 20 °C

8.1: hydrogenchloride / ethyl acetate / 0.67 h / 0 °C

9.1: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide / 17.5 h / 20 °C

With pyridine; hydrogenchloride; dmap; boron trifluoride diethyl etherate; water; sodium formate; sodium hydride; benzotriazol-1-ol; Dess-Martin periodane; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; camphor-10-sulfonic acid; In tetrahydrofuran; methanol; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;