[3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

Base Information

Chemical Name:[3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol
CAS No.:144318-37-6
Molecular Formula:C₂₄H₂₅NO₄S
Molecular Weight:423.533
Hs Code.:

Synonyms:[3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

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Technology Process of [3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

There total 9 articles about [3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

: 144318-36-5
3-Benzyloxymethyl-3-(tetrahydro-pyran-2-yloxymethyl)-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indole

: 144318-37-6
[3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

Guidance literature:: With Amberlyst-H-15; In methanol; at 45 ℃; for 4h;
DOI:10.1021/ja00050a012

Reference yield:

: 4039-82-1
Benzyl propargyl ether

: 144318-37-6
[3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: 93 percent / mercury(II) oxide, aq. H₂SO₄ / 0.17 h / 60 °C

2: Br₂ / 6 h / 23 °C

3: aq. F₃CCOOH / 10 h / 23 °C

4: 1.) NaH / 1.) DMF

5: 1.) HMPA / 1.) THF, 2.) THF, 25 deg C, 48 h

6: 61 percent / Bu₂SnH, AIBN / benzene / 80 °C

7: 97 percent / Amberlyst-H-15 / methanol / 4 h / 45 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); Amberlyst-H-15; sulfuric acid; bromine; sodium hydride; trifluoroacetic acid; mercury(II) oxide; In methanol; benzene;
DOI:10.1021/ja00050a012

Reference yield:

: 22539-93-1
3-benzyloxypropanone

: 144318-37-6
[3-Benzyloxymethyl-1-(toluene-4-sulfonyl)-2,3-dihydro-1H-indol-3-yl]-methanol

Guidance literature:: Multi-step reaction with 6 steps

1: Br₂ / 6 h / 23 °C

2: aq. F₃CCOOH / 10 h / 23 °C

3: 1.) NaH / 1.) DMF

4: 1.) HMPA / 1.) THF, 2.) THF, 25 deg C, 48 h

5: 61 percent / Bu₂SnH, AIBN / benzene / 80 °C

6: 97 percent / Amberlyst-H-15 / methanol / 4 h / 45 °C

With N,N,N,N,N,N-hexamethylphosphoric triamide; 2,2'-azobis(isobutyronitrile); Amberlyst-H-15; bromine; sodium hydride; trifluoroacetic acid; In methanol; benzene;
DOI:10.1021/ja00050a012